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Thyroid hormone-like drug induces hair growth
Bioorg Med Chem Lett. 2009
Thyroid receptor agonists for the treatment of androgenetic alopecia (male pattern hair loss).
Li JJ, et al
A thyroid hormone receptor beta subtype-selective thyromimetic 5 was found to be efficacious in both mouse and monkey hair growth models after topical applications. It penetrates the skin according to the test in human cadaver skin mounted onto Franz diffusion chambers. The serum drug level of 5 is below the limit of quantification during tests in the bald stump-tailed macaques (Macaca arctoides). It is tested negative in the 3T3 neutral red uptake (NRU) phototoxicity test, indicating a low risk for causing photo-irritation. It is also rapidly metabolized according to the PK data, thus the systemic exposure is limited.
Dr Proctor comments: Hmm, a topical thyroid hormone analog stimulates hair regrowth. From Pfizer too. About one in four persons with hair loss due to alopecia areata has thyroid disease. They seem to do better if they fix the low thyroid levels.
Edited for hair loss blog use