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Alefacept for severe alopecia areata
Arch Dermatol. 2009;145:1262
Alefacept for severe alopecia areata
Strober BE,et al
OBJECTIVE: To assess the efficacy of alefacept for the treatment of hair loss due to severe alopecia areata (AA). DESIGN: Multicenter, double-blind, randomized, placebo-controlled clinical trial. SETTING: Academic departments of dermatology in the United States. PARTICIPANTS: Forty-five individuals with chronic and severe AA affecting 50% to 95% of the scalp hair and resistant to previous therapies. Intervention Alefacept, a US Food and Drug Administration-approved T-cell biologic inhibitor for the treatment of moderate to severe plaque psoriasis. Main Outcome Measure Improved Severity of Alopecia Tool (SALT) score over 24 weeks. RESULTS: Participants receiving alefacept for 12 consecutive weeks demonstrated no statistically significant improvement in AA when compared with a well-matched placebo-receiving group. Conclusion Alefacept is ineffective for the treatment of hair losss in alopecia areata.
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